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These tails are topic to a number of post-translational covalent modifications, including acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ). Methylation been discovered on a range of lysine residues in various histones: K4 (utilizing the only-letter amino-acid code for lysine), K9, K27, K36 and K79 in histone H3, K20 in histone H4, K59 in the globular domain of histone H4 2 and K26 of histone H1B 3 Several proteins responsible for the methylation of particular residues have been characterised, and all however certainly one of these contains a SET area

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