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| This family comprises only one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was discovered to methylate, apart from histone, quite a lot of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and elements of the TATA binding protein (TBP) advanced, TBP-related factors TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Ok/R-S/T-Ok (goal lysine is bold), [legal practice](https://en.startdir.de/user/profile/Fermin61V66) can also be recognized by the H3K4 demethylase KDM1A/LSD1, which is capable of eradicating the methyl mark on most of those substrates 17 , ninety four Subsequently KMT7/KDM1A has emerged as a classic mannequin for dynamic lysine methylation of both histone and non-histone proteins. | |||
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| Methylation of p53 protein by KMT7/SET7 is the primary reported KMT-mediated methylation event on a non-histone protein 18 Since that discovery, a number of KMTs, as well as KDM1A, have been recognized as p53 regulators that methylate or demethylate p53 protein, making p53 probably the most extensively studied non-histone protein present process lysine methylation 4 , 13 , sixteen , 18 , 162 Here we use p53 as a mannequin to debate the features of lysine methylation of non-histone proteins. | |||
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